Acetyl tetrapeptide-3 powder

What is Acetyl tetrapeptide-3?

Acetyl tetrapeptide-3 powder is a biomimetic peptide composed of four amino acids that can imitate the effects of natural peptides in the human body, stimulating cell proliferation and controlling cell differentiation, participating in intercellular communication and stimulating hair follicle development. At the same time, Acetyl tetrapeptide-3 can accelerate the formation of extracorporeal matrix (ECM) proteins, such as adhesin, collagen III and VII, etc., thereby effectively improving the structure of hair follicles and increasing the stability of hair anchoring. Since acetyl tetrapeptide-3 is a peptide synthesized from amino acids, it will not have any side effects when used in the human body for a long time, and is very suitable for long-term treatment of hair loss. In a word, acetyl tetrapeptide-3 is a compound raw material that can prevent hair loss and promote hair growth.

Acetyl tetrapeptide-3 can accelerate the formation of extracorporeal matrix (ECM) proteins, such as adhesin, collagen III and VII, etc., thereby effectively improving the structure of hair follicles and increasing the anchoring stability of Chemicalbook hair. Since acetyl tetrapeptide-3 is a peptide synthesized from amino acids, it will not have any side effects when used in the human body for a long time, and is very suitable for long-term treatment of hair loss.

What are the benefits?

Acetyl tetrapeptide-3 cannot directly reduce DHT, but it can enhance the hair follicle's resistance to DHT. It can stimulate the hair papilla and accelerate ECM protein synthesis, increasing the volume of hair follicles; repairing the epidermal-dermal junction tissue (DEJ), promoting the fixation of hair in hair follicles, and stimulating hair growth; it can also effectively reduce hair loss caused by aging. Makes hair thicker, natural, smoother and tighter. At the same time, acetyl tetrapeptide-3 can cooperate with other raw materials that inhibit 5α-reductase to prevent hair loss and hair growth, achieving the effect of 1+1>2.

In order to prove the effect of acetyl tetrapeptide-3 on preventing hair loss, researchers conducted 5 in vitro and in vivo experiments.

01Synthesis of collagen

Collagen proteins such as adhesion protein, collagen III and VII, etc., can keep the ECM protein intact, thereby better fixing the hair follicles. Collagen contains two specific amino acids: hydroxylysine and hydroxyproline. Hydroxyproline content is positively correlated with collagen production. Dermal papilla cells synthesize proteins and collagen similarly to skin fibroblasts. By comparing the hydroxyproline content produced by human fibroblasts with/without the addition of acetyl tetrapeptide-3, the effect of acetyl tetrapeptide-3 on Effects on collagen synthesis.

The data showed that cells treated with acetyl tetrapeptide-3 showed high levels of hydroxyproline, indirectly proving that acetyl tetrapeptide-3 stimulates collagen production and also means that the compound stimulates dermal papilla collagen. of generation.

Figure 10. Hydroxyproline content in fibroblasts

02Stimulation of ECM protein synthesis

In order to prove the effect of acetyl tetrapeptide-3 on ECM proteins, the researchers used selective immunofluorescence to compare fibroblasts using/without acetyl tetrapeptide-3 to observe the synthesis of ECM proteins. Immunofluorescence is a technique that uses fluorescent agents to provide highly specific visualization of cellular components, such as a universal fluorescent protein - GFP - attached to the target protein.

Data show that acetyl tetrapeptide-3 can strongly induce the synthesis of ECM proteins such as laminin and collagen III, increasing laminin content and collagen III content by 65% and 285% respectively, and stimulating skin remodeling. , causing the hair follicles to enlarge.

Figure 11. Stimulation of ECM protein synthesis by fibroblasts

03Key points

Researchers isolated healthy human hair follicles from human scalp skin through microdissection and cultured them in culture media with or without 0.0006% acetyl tetrapeptide-3 for 8 days to measure acetyl tetrapeptide-3. Effects on the growth rate of hair shafts on human hair follicles.

The results showed that after 8 days, compared with untreated hair follicles, the hair shaft growth length of hair follicles treated with acetyl tetrapeptide-3 increased by 35%, proving that acetyl tetrapeptide-3 can strongly stimulate human hair growth.

Figure 12. Hair length measurement

Healthy human hair follicles were isolated from the dermis-subcutaneous fat interface of human scalp skin through microdissection, and cultured in culture medium supplemented with acetyltetrapeptide-3 and minoxidil for 7 days, with a micrometer every 24 hours. Clamp the two hair follicles under a microscope to optically measure the growth rate of the hair shaft. Data show that acetyl tetrapeptide-3 can strongly stimulate the growth of human hair, and the growth rate is higher than that of minoxidil.

Figure 13. Hair growth rate of minoxidil and acetyltetrapeptide-3

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