Geniposide Powder

What Is Geniposide Powder?

Geniposide Powder is a product extracted and refined from the dried mature fruits of the Rubiaceae plant Gardenia using high-tech production processes. Gardenia glycoside is an iridoid glycoside compound, with synonyms of geniposide, dumeizixin glucoside and dehydroxygardenia glycoside. The pure product is a white powder with high solubility in water, but insoluble in petroleum ether. Gardenia glycoside powder has many uses. Fermentation under different conditions can make natural edible colorants Gardenia blue and Gardenia red. It is also a raw material drug for the treatment of cardiovascular and cerebrovascular diseases, liver and gallbladder diseases and diabetes.

The chemical components that have been found in Gardenia mainly include iridoids, monoterpene glycosides, diterpenes, triterpenes, organic acid esters, flavonoids, volatile oils, polysaccharides and various trace elements. Iridoid compounds are a class of monoterpene derivatives with cyclopentane, which mainly exist in the form of glycosides in Gardenia fruits.

Geniposide Powder have a variety of pharmacological effects, including laxative, analgesic, choleretic, anti-inflammatory, treatment of soft tissue injuries, inhibition of gastric juice secretion and reduction of pancreatic amylase, etc. It also has a variety of effects such as liver protection, blood pressure reduction, prevention and treatment of atherosclerosis and thrombosis, sedation, and antimicrobial effects.

What Are The Effects Of Geniposide Powder?

Anti-inflammatory

Geniposide Powder can reduce inflammatory symptoms by regulating the expression of inflammatory-related factors. For example, in studies, Gardenia glycoside can inhibit the production of inflammatory cytokines and the activation of NF-κB, thereby improving colitis and intestinal barrier damage.

Antioxidant

It has antioxidant capacity, can reduce lipid peroxidation, and restore redox homeostasis, thereby fighting inflammation and oxidative stress.

Cholestatic and liver-protective

It can promote gallbladder contraction, help expel stones, and has a protective effect on liver cells, can reduce serum transaminase levels, and has an inhibitory effect on liver cancer cells.

Sedative

Geniposide acts on the central nervous system and has a certain sedative effect, and also has a certain antihypertensive effect.

Anti-gastric acid secretion

Geniposide has a certain inhibitory effect on gastric acid secretion and helps protect the gastric mucosa.

Anti-atherosclerosis

It has anti-atherosclerotic effects and helps protect cardiovascular health.

Anti-thrombotic

The blockage of endothelial cell growth after vascular injury can cause atherosclerosis and thrombosis. Gardenia glycoside can promote the growth of basic primitive fibroblast growth factor in cells, and is an effective substance for preventing atherosclerosis and anti-thrombosis.

Treatment of osteoarthritis

Geniposide can promote the proliferation of ligament fibroblasts, promote tissue repair and healing of ligament injuries, and has a certain therapeutic effect on osteoarthritis.

Lower cholesterol

Although the lipid-lowering effect of gardenia glycoside is still controversial, some studies believe that it achieves the lipid-lowering effect by promoting bile secretion.

Hemostasis

Geniposide also has the important functions of cooling blood and stopping bleeding. People can quickly stop bleeding by applying purified gardenia glycoside directly to the wound, and it can prevent infection of the wound. When people have diseases such as vomiting blood, coughing up blood, and bloody stools, supplementing the body with gardenia glycoside can also relieve bleeding symptoms. Its hemostatic effect is particularly obvious.

Relieve swelling and relieve pain

It is a medicinal ingredient that can relieve swelling and relieve pain. It can be used as a surgical medicine to treat human traumatic injuries. During treatment, the purified gardenia glycoside can be mixed with rice wine to make an ointment and then applied to the injured area. Change the ointment once a day and use it continuously for two to three days, and the swelling and pain will be reduced or disappear.

Relieve high fever

It is a natural medicinal ingredient. It tastes bitter and cold in nature. It can clear away heat and relieve fire, and can also relieve high fever. People can take some gardenia glycosides when they have high fever or irritability. It can restore human body temperature to normal as soon as possible and relieve human high fever symptoms quickly.

Gardenia glycoside improves DSS-induced ulcerative colitis through KEAP1-Nrf2 signaling pathway

Gardenia glycoside can bind to KEAP1, thereby disrupting the interaction between KEAP1 and Nrf2, preventing Nrf2 degradation and activating the Nrf2/ARE signaling pathway, ultimately inhibiting the occurrence of inflammation caused by redox imbalance.

It can alleviate DSS-induced colitis.

It improves DSS-induced intestinal barrier damage.

It inhibits the production of inflammatory cytokines and the activation of NF-κB in DSS-stimulated colon tissue.

It reduces oxidative stress and activates Nrf2/ARE signaling in DSS-stimulated colon tissue.

It reduces the production of proinflammatory cytokines in LPS-induced Caco2 cells and inhibits the activation of the NF-κB pathway.

It can improve oxidative stress and activate the Nrf2/ARE pathway in LPS-stimulated Caco2 cells.

It can improve the inflammatory response induced by LPS that depends on the Nrf2/ARE signaling pathway.

It may bind to KEAP1.

In What Fields Is Geniposide Powder Used?

Food field

Geniposide Powder can be made into natural food colorants Gardenia blue and Gardenia red under different fermentation conditions. This is because Gardenia glycoside is an effective ingredient extracted from Gardenia, which is converted into a substance that can be used for food coloring through fermentation and other processes. In the food industry, natural food colorants are more popular with consumers than synthetic pigments because of their high safety and natural sources.

Medical field

Treatment of various diseases

Cardiovascular and cerebrovascular diseases: Geniposide has certain pharmacological effects and affects the cardiovascular and cerebrovascular systems. For example, its water extract or alcohol extract has a hypotensive effect regardless of oral, intraperitoneal or intravenous administration. Intravenous administration has a rapid hypotensive effect and a short duration, which indicates that Gardenia glycoside may have potential medicinal value in the treatment of cardiovascular and cerebrovascular diseases such as hypertension.

Hepatobiliary diseases: Geniposide has a protective and therapeutic effect on the liver and gallbladder. Gardenia has a significant gallbladder contraction effect, which is significantly greater than water and even close to the effect of a high-fat meal, so Gardenia glycoside can be used to promote gallbladder and expel stones. Gardenia extract has a significant effect on reducing the increase of GOT in ligated common bile duct and can increase the amount of Y and Z proteins in normal animals.

Diabetes: Geniposide is a raw material drug for the treatment of diabetes. Although the specific mechanism of action may be more complicated, it is a compound with multiple biological activities and has certain significance in the treatment and research of diabetes.

Arrhythmia: There is a patent indicating that gardenia glycoside can be used to prepare drugs for the treatment of arrhythmia, which expands the application range of gardenia glycoside in the treatment of cardiovascular diseases.

Soft tissue injury: Geniposide has the effect of treating soft tissue injury. Its specific treatment mechanism may be related to its anti-inflammatory, analgesic and other pharmacological effects, which can relieve the pain, inflammation and other symptoms caused by soft tissue injury.

Digestive system diseases

Effects on gastric function: Gardenia crude drug and various processed products have different effects on gastric acid secretion and pepsin activity in hungry mice. Geniposide, administered intraduodenally at 25 mg/kg, inhibits gastric acid secretion in pylorus-ligated rats. Among the hypersecretion of gastric acid caused by carbachol, tetragastrin, and histamine, only carbachol is inhibited, which indicates that gardenia glycoside has a regulatory effect on gastric function.

Effects on acute pancreatitis: Gardenia extract has a significant effect on reducing the activity level of lipid peroxides in serum and tissues of rats with severe pancreatitis (SAP), which helps to reduce pancreatic damage, maintain the body's own antioxidant capacity, and reduce the damage caused to the body by oxygen free radicals and their cascade reactions during SAP.

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YTBIO is developing in an all-round way. We have our own factory, quality inspection and R&D team. We are committed to providing customers with the best quality Geniposide Powder and services. It is our original intention to let every consumer enjoy high-quality and healthy products. If you have any needs or questions about our products, please feel free to contact us and we will reply you as soon as possible.

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